Article

Gene regulatory network topology governs resistance and treatment escape in glioma stem-like cells

2024-02-07

Abstract excerpt

<h4>ABSTRACT</h4> Poor prognosis and drug resistance in glioblastoma (GBM) can result from cellular heterogeneity and treatment-induced shifts in phenotypic states of tumor cells, including dedifferentiation into glioma stem-like cells (GSCs). This rare tumorigenic cell subpopulation resists temozolomide, undergoes proneural-to-mesenchymal transition (PMT) to evade therapy, and drives recurrence. Through inferenc...

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Literature Corpus work: 3f080e66-08dd-5884-ab5f-b33d105729f6
DOI: 10.1101/2024.02.02.578510

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