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Gene regulatory network topology governs resistance and treatment escape in glioma stem-like cells

7 Jun 2024

Abstract excerpt

Poor prognosis and drug resistance in glioblastoma (GBM) can result from cellular heterogeneity and treatment-induced shifts in phenotypic states of tumor cells, including dedifferentiation into glioma stem-like cells (GSCs). This rare tumorigenic cell subpopulation resists temozolomide, undergoes proneural-to-mesenchymal transition (PMT) to evade therapy, and drives recurrence. Through inference of...

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PMID: 38848360
DOI: 10.1126/sciadv.adj7706

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