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Article

Identifying clinically relevant cell state interactions in the tumor microenvironment of IDH-mutant gliomas using CSI-TME.

Molecular systems biology - 1 Jun 2026

Singh Arashdeep, Mehani Bharati, Gopalan Vishaka, Puri Sushant, Aldape Kenneth, Hannenhalli Sridhar

Abstract excerpt

Tumor microenvironment (TME) is characterized by a milieu of distinct cell types that exist in heterogenous transcriptional states across tumors. Functional interactions among these cell states drive tumor progression and therapy response. Systematic characterization of functional cell-state interactions (CSIs) remains challenging due to the paucity of scRNA-seq cohorts with clinical information on one hand, and...

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PMID: 41807578
DOI: 10.1038/s44320-026-00201-0
PMCID: PMC13230996

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