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Article

Human myxomatous mitral valve prolapse: role of bone morphogenetic protein 4 in valvular interstitial cell activation.

Journal of cellular physiology - 1 Jun 2012

Sainger Rachana, Grau Juan B, Branchetti Emanuela, Poggio Paolo, Seefried William F, Field Benjamin C, Acker Michael A, Gorman Robert C, Gorman Joseph H, Hargrove Clark W, Bavaria Joseph E, Ferrari Giovanni

Abstract excerpt

Myxomatous mitral valve prolapse (MVP) is the most common cardiac valvular abnormality in industrialized countries and a leading cause of mitral valve surgery for isolated mitral regurgitation. The key role of valvular interstitial cells (VICs) during mitral valve development and homeostasis has been recently suggested, however little is known about the molecular pathways leading to MVP. We aim to characterize...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22105615
DOI: 10.1002/jcp.22999
PMCID: PMC3288540

Genes

MVP
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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