Article
Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2013
Wang Huan, Tibbitt Mark W, Langer Stephen J, Leinwand Leslie A, Anseth Kristi S
Abstract excerpt
Matrix elasticity regulates proliferation, apoptosis, and differentiation of many cell types across various tissues. In particular, stiffened matrix in fibrotic lesions has been shown to promote pathogenic myofibroblast activation. To better understand the underlying pathways by which fibroblasts mechano-sense matrix elasticity, we cultured primary valvular interstitial cells (VICs) isolated from porcine aortic...
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