Article
Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo.
Scientific reports - 16 Nov 2020
Motta Sarah E, Fioretta Emanuela S, Lintas Valentina, Dijkman Petra E, Hilbe Monika, Frese Laura, Cesarovic Nikola, Loerakker Sandra, Baaijens Frank P T, Falk Volkmar, Hoerstrup Simon P, Emmert Maximilian Y
Abstract excerpt
Regenerative tissue-engineered matrix-based heart valves (TEM-based TEHVs) may become an alternative to currently-used bioprostheses for transcatheter valve replacement. We recently identified TEM-based TEHVs-geometry as one key-factor guiding their remodeling towards successful long-term performance or failure. While our first-generation TEHVs, with a simple, non-physiological valve-geometry, failed over time...
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