Article

Biomimetic biaxial mechanical properties enhance hemodynamic performance and prevent adverse tissue remodelling in tissue-engineered heart valves

2025-03-07

Abstract excerpt

Heart valve tissue engineering holds the promise of providing an unlimited supply of heart valve replacements for patients with valvular heart disease. While tissue-engineered heart valves show promising performance in the short term, regurgitation due to fibrotic leaflet shortening remains a persistent limitation in most cases. Here we tested the hypothesis that engineering heart valves with native biaxial mechan...

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Identifiers and source

Literature Corpus work: 55494708-0354-5053-be58-fe63655e6d5f
DOI: 10.1101/2025.03.02.641050

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