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Article

Unraveling Mechanisms of Genetic Risks in Metabolic Dysfunction-Associated Steatotic Liver Diseases: A Pathway to Precision Medicine.

Annual review of pathology - 1 Jan 2025

Zhang Xiang, Chang Kyong-Mi, Yu Jun, Loomba Rohit

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health problem, affecting ∼1 billion people. This condition is well established to have a heritable component with strong familial clustering. With the extraordinary breakthroughs in genetic research techniques coupled with their application to large-scale biobanks, the field of genetics in MASLD has expanded rapidly. In this...

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PMID: 39854186
DOI: 10.1146/annurev-pathmechdis-111523-023430

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