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Article

HDI-STARR-seq Identifies Functional GH-regulated Sex-Biased Hepatocyte Enhancers Linked to Liver Metabolism and Disease

2025-11-04

Abstract excerpt

Growth hormone (GH) controls sexual dimorphism in hepatocyte gene expression programs governing lipid metabolism, bile acid synthesis and xenobiotic processing, which contribute to sex differences in metabolic dysfunction-associated steatotic liver disease (MASLD) risk. Despite extensive study of GH-regulated sex differences in gene transcription, the functional cis -regulatory hepatocyte enhancers that orchestra...

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Literature Corpus work
89bd0436-84f1-5786-b02d-6301cff733a3
DOI
10.1101/2025.11.02.686175
Open publication

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HDI-STARR-seq Identifies Functional GH-regulated Sex-Biased Hepatocyte Enhancers Linked to Liver Metabolism and DiseaseDOI 10.1101/2025.11.02.686175
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