Article

Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression

2024-05-21

Abstract excerpt

Development of ipsilateral breast carcinoma following diagnosis of breast ductal carcinoma in situ (DCIS) has been assumed to represent recurrence of the primary tumour. However, this may not be the case and it is important to know how often recurrences are new tumours. Ipsilateral primary-recurrence pairs (n=78) were sequenced to test their clonal relatedness. Shared genetic events were identified from whole exom...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ef48efe-5750-5342-ae69-f0018bdda8e8
DOI: 10.1101/2024.05.19.594731

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progressionDOI 10.1101/2024.05.19.594731Read

Genomic profiling defines variable clonal relatedness between invasive breast cancer and primary ductal carcinoma <i>in situ</i>Semantic proximity Read

Ipsilateral Breast Carcinoma Recurrence: True Recurrence or New Primary? A Clinicopathologic and Molecular Study.Semantic proximity Read

Proteogenomics decodes the evolution of human ipsilateral breast cancerSemantic proximity Read

Evolutionary Measures Show that Recurrence of DCIS is Distinct from Progression to Breast CancerSemantic proximity Read

Inter-tumor genomic heterogeneity of breast cancers: comprehensive genomic profile of primary early breast cancers and relapses.Semantic proximity Read

”Evolution of ipsilateral breast cancer decoded by proteogenomics”Semantic proximity Read

Identifying Locally Recurrent Versus Second Primary Breast Cancer: Genomic Versus Clinical Criteria from Carolina Breast Cancer Study Phase III.Semantic proximity Read

High-Resolution Mapping of DNA Breakpoints to Define True Recurrences Among Ipsilateral Breast CancersSemantic proximity Read

Chromosomal Alterations in Ductal Carcinomas In Situ and Their In Situ RecurrencesSemantic proximity Read

Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapySemantic proximity Read

Comparative Genomic Profiling of Second Breast Cancers following First Ipsilateral Hormone Receptor-Positive Breast Cancers.Semantic proximity Read

Genomic and transcriptomic evaluation of primary and recurrent luminal B-like breast cancer.Semantic proximity Read