Article
Identifying Locally Recurrent Versus Second Primary Breast Cancer: Genomic Versus Clinical Criteria from Carolina Breast Cancer Study Phase III.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 3 Feb 2026
Van Alsten Sarah C, Love Michael I, Calhoun Benjamin C, Butler Eboneé N, Pfefferle Adam D, Kirk Erin L, Halloran Christopher S, Zipple Isaiah W, Perou Charles M, Carey Lisa A, Hoadley Katherine A, Troester Melissa A
Abstract excerpt
BACKGROUND: Treatment approaches differ for isolated in-breast tumor recurrence (representing treatment failure) and new primary breast tumors (representing high etiologic risk). However, methods for distinguishing recurrences from second primaries (based on radiographic and histologic criteria) are subject to error. Gold-standard genomic datasets for assessing classification accuracy have been lacking. METHODS:...
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