Article

Mutational landscape of pure ductal carcinoma in situ and associations with disease prognosis and response to radiotherapy

2025-03-03

Abstract excerpt

<h4>Background</h4> Managing Ductal Carcinoma in Situ (DCIS) remains challenging due to the lack of reliable biomarkers to predict radiotherapy (RT) response, leading to both overtreatment of indolent disease and undertreatment of aggressive cases. <h4>Results</h4> Through whole-exome sequencing of 147 DCIS cases, we characterized the genomic landscape of pure DCIS and identified genetic alterations associated wit...

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Literature Corpus work: 91ac0850-d8e1-50ab-9744-8d4797cde3a4
DOI: 10.1101/2025.03.01.25323122

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