Article

Evolutionary Measures Show that Recurrence of DCIS is Distinct from Progression to Breast Cancer

2024-08-16

Abstract excerpt

Progression from pre-cancers like ductal carcinoma in situ (DCIS) to invasive disease (cancer) is driven by somatic evolution and is altered by clinical interventions. We hypothesized that genetic and/or phenotypic intra-tumor heterogeneity would predict clinical outcomes for DCIS since it serves as the substrate for natural selection among cells. We profiled two samples from two geographically distinct foci from...

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Literature Corpus work: 080d44d5-5aa2-57e5-9679-6443ee101c96
DOI: 10.1101/2024.08.15.24311949

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