Article

A long-read RNA sequencing and polysome profiling framework reveals transposable element–driven transcript diversity and translational rewiring in glioblastoma

2026-04-21

Abstract excerpt

<h4>Background</h4> Transposable elements (TEs) account for over half of the human genome and are often derepressed in cancer. TEs can add cryptic splice sites, undergo exonization, and generate gene–TE fusion transcripts, but the combined effects of TEs on RNA processing and translation in glioblastoma stem cells (GSCs) remains incompletely elucidated. <h4>Results</h4> We combined long-read RNA sequencing with...

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Literature Corpus work: 5bd7fad6-626a-5f90-b5f1-bd01b9677df3
DOI: 10.64898/2026.04.18.719388

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