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Article

Reanalysis of RNA-sequencing data reveals several additional fusion genes with multiple isoforms.

PloS one - 1 Jan 2012

Kangaspeska Sara, Hultsch Susanne, Edgren Henrik, Nicorici Daniel, Murumägi Astrid, Kallioniemi Olli

Abstract excerpt

RNA-sequencing and tailored bioinformatic methodologies have paved the way for identification of expressed fusion genes from the chaotic genomes of solid tumors. We have recently successfully exploited RNA-sequencing for the discovery of 24 novel fusion genes in breast cancer. Here, we demonstrate the importance of continuous optimization of the bioinformatic methodology for this purpose, and report the discovery...

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Source

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Identifiers

PMID: 23119097
DOI: 10.1371/journal.pone.0048745
PMCID: PMC3485361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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