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Discovery of non-canonical proteins through modification-aware proteogenomics

2026-08-20

Abstract excerpt

The SwissProt database contains a stable 20,418 human protein-coding genes and 42,541 human protein sequences. Ribo-Seq suggests about 7,000 additional, non-canonical Open Reading Frames (ORFs) are present in humans, though only a few of them are confirmed by Mass Spectrometry (MS). Detecting these proteins requires extensive database searches, increasing computational load and inflating False Discovery Rates (FDR...

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Literature Corpus work
d57f96b9-467b-5185-a43c-46a43ad20381
DOI
10.64898/2026.08.17.745157
Open publication

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Discovery of non-canonical proteins through modification-aware proteogenomicsDOI 10.64898/2026.08.17.745157
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