Mapping the Human Ghost Proteome: Classification and Experimental Detection Biases in the Identification of Alternative Microproteins

Abstract excerpt

The discovery of alternative proteins (AltProts), translated from non-canonical ORFs, has expanded the human proteome and revealed a hidden layer known as the ghost proteome. Despite increasing evidence, AltProts detection remains challenging due to their small size, physicochemical heterogeneity, and lack of annotation. Here, we developed an integrated bioinformatic and proteomic workflow to benchmark the detecti...

Topics

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• Alternative Splicing
• Databases, Protein
• Gene Ontology
• Molecular Sequence Annotation
• Protein Isoforms
• Protein Processing, Post-Translational
• Proteome
• User-Computer Interface

Identifiers and source

Literature Corpus work

2412245c-ff57-5670-8c26-3f07bd8f4aae

DOI

10.64898/2026.07.31.741785