Article

Overdosage of balanced protein complexes reduces proliferation rate in aneuploid cells

2018-07-25

Abstract excerpt

<h4>SUMMARY</h4> Cells with complex aneuploidies, such as tumor cells, display a wide range of phenotypic abnormalities. However, molecular basis for this has been mainly studied in trisomic (2 n +1) and disomic ( n +1) cells. To determine how karyotype affects proliferation rate in cells with complex aneuploidies we generated forty 2 n+x yeast strains in which each diploid cell has an extra 5 to 12 chromosome...

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Literature Corpus work: 134c3f6c-cc60-5c95-8e33-e8b5a5890c30
DOI: 10.1101/376988

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