Article
Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2014
Foijer Floris, Xie Stephanie Z, Simon Judith E, Bakker Petra L, Conte Nathalie, Davis Stephanie H, Kregel Eva, Jonkers Jos, Bradley Allan, Sorger Peter K
Abstract excerpt
Aneuploidy is a hallmark of human solid cancers that arises from errors in mitosis and results in gain and loss of oncogenes and tumor suppressors. Aneuploidy poses a growth disadvantage for cells grown in vitro, suggesting that cancer cells adapt to this burden. To understand better the consequences of aneuploidy in a rapidly proliferating adult tissue, we engineered a mouse in which chromosome instability was...
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