Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development.

Nature communications - 15 Jan 2024

Shah Amil M, Myhre Peder L, Arthur Victoria, Dorbala Pranav, Rasheed Humaira, Buckley Leo F, Claggett Brian, Liu Guning, Ma Jianzhong, Nguyen Ngoc Quynh, Matsushita Kunihiro, Ndumele Chiadi, Tin Adrienne, Hveem Kristian, Jonasson Christian, Dalen Håvard, Boerwinkle Eric, Hoogeveen Ron C, Ballantyne Christie, Coresh Josef, Omland Torbjørn, Yu Bing

Abstract excerpt

Heart failure (HF) causes substantial morbidity and mortality but its pathobiology is incompletely understood. The proteome is a promising intermediate phenotype for discovery of novel mechanisms. We measured 4877 plasma proteins in 13,900 HF-free individuals across three analysis sets with diverse age, geography, and HF ascertainment to identify circulating proteins and protein networks associated with HF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix Proteins

Share to Glycoproteins

Share to Heart Failure

Share to Phenotype

Share to Proteomics

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 38225249
DOI: 10.1038/s41467-023-44680-3
PMCID: PMC10789789

Genes

CCL15
CFH
FSTL3
IGFBP7
ITIH3
MFAP4
SPON1
SVEP1
VTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development.PMID 38225249Read ↗

Plasma protein profiles in different heart failure phenotypes.Semantic proximity Read ↗

Clinical-transcriptional prioritization of the circulating proteome in human heart failureSemantic proximity Read ↗

Mendelian Randomization of Circulating Proteome Identifies Actionable Targets in Heart FailureSemantic proximity Read ↗

Profiling of the plasma proteome across different stages of human heart failureSemantic proximity Read ↗

Mendelian randomization of circulating proteome identifies actionable targets in heart failureSemantic proximity Read ↗

Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart StudySemantic proximity Read ↗

Proteomic Associations of Adverse Outcomes in Human Heart FailureSemantic proximity Read ↗

A multi-layered approach to elucidate mechanisms of physical function in response to rehabilitation in heart failure with preserved ejection fractionSemantic proximity Read ↗

Proteomic Profiling of Early-Stage Heart Failure Identifies Candidate Biomarkers and Molecular Pathways of Cardiac Inflammation in the Project Baseline Health StudySemantic proximity Read ↗

Proteomics Identify Clinical Phenotypes and Predict Functional Outcomes in Heart Failure With Preserved Ejection Fraction: Insights From VITALITY-HFpEF.Semantic proximity Read ↗

Integrative proteomic analyses across common cardiac diseases yield mechanistic insights and enhanced predictionSemantic proximity Read ↗

Systemic Biomarkers and Unique Pathways in Different Phenotypes of Heart Failure with Preserved Ejection Fraction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.