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Article

Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis of the Blood Proteome.

Cardiovascular drugs and therapy - 1 Dec 2024

Ning Zuodong, Huang Yunying, Lu Haocheng, Zhou Yong, Tu Tao, Ouyang Feifan, Liu Yaozhong, Liu Qiming

Abstract excerpt

PURPOSE: Novel, effective, and safe preventive therapy targets for AF are still needed. Circulating proteins with causal genetic evidence are promising candidates. We aimed to systematically screen circulating proteins for AF drug targets and determine their safety and efficacy using genetic methods. METHODS: The protein quantitative trait loci (pQTL) of up to 1949 circulating proteins were retrieved from nine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37212950
DOI: 10.1007/s10557-023-07467-8

Genes

TNFSF12
ALAD
ANXA4
B3GNT8
CFL2
CHMP3
CTSZ
EFEMP1
FBP1
FCGR2A
FKBP7
FLRT2
IL6R
LPA
MANBA
MTHFD1
NEO1
OLA1
PFKM
PMVK
QSOX2
RAB1A
SH3BGRL3
SPON1
SRL
SYT11
TES
UBE2F

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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