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Article

Genetic drug target validation using Mendelian randomisation.

Nature communications - 26 Jun 2020

Schmidt Amand F, Finan Chris, Gordillo-Marañón Maria, Asselbergs Folkert W, Freitag Daniel F, Patel Riyaz S, Tyl Benoît, Chopade Sandesh, Faraway Rupert, Zwierzyna Magdalena, Hingorani Aroon D

Abstract excerpt

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal relevance of environmental and biological risk factors for disease. However, causal inference is undermined if genetic variants used to instrument a risk factor also influence alternative disease-pathways (horizontal pleiotropy). Here we report how the 'no horizontal pleiotropy assumption' is strengthened when proteins are the risk...

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Identifiers

PMID: 32591531
DOI: 10.1038/s41467-020-16969-0
PMCID: PMC7320010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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