Article

Low-Density Lipoprotein Cholesterol and Dementia Risk: Integrating Mendelian Randomization and Target Trial Emulation Within the Heart–Brain Axis

2026-06-17

Abstract excerpt

<h4>Background</h4> The heart–brain axis links cardiovascular and neurodegenerative disease through shared vascular and inflammatory mechanisms. Although low-density lipoprotein cholesterol ( LDL-C) is an established causal factor in atherosclerotic cardiovascular disease (ASCVD), its relationship with dementia remains uncertain, with midlife elevations associated with increased risk but late-life associations o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fef54a2f-5a2b-518a-8e17-ba385794ad5b
DOI: 10.64898/2026.06.10.26355413

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low-Density Lipoprotein Cholesterol and Dementia Risk: Integrating Mendelian Randomization and Target Trial Emulation Within the Heart–Brain AxisDOI 10.64898/2026.06.10.26355413Read

Atherosclerosis and dementia - causal aspects and preventive potential.Semantic proximity Read

Repurposing drugs for the prevention of vascular dementia: Evidence from drug target Mendelian randomizationSemantic proximity Read

The heterogeneous treatment effects of statins on dementia: a target trial emulation with causal machine learning using integrated genetic and real-world data.Semantic proximity Read

Mendelian randomization of dyslipidemia on cognitive impairment among older AmericansSemantic proximity Read

Causal relationship between cholesterol-lowering therapy and Alzheimer Disease: evidence from genetic correlation and Mendelian randomization studySemantic proximity Read

Causal insights of modifiable cardiovascular risk factors for dementia risk - potential for efficient prevention and improved brain health.Semantic proximity Read

Genetic insights of lipid metabolism and lipid-lowering drugs with Lewy body dementia risk: Evidence from Mendelian randomization.Semantic proximity Read

Efficacy and safety of low levels of low-density lipoprotein cholesterol: trans-ancestry linear and non-linear Mendelian randomization analysesSemantic proximity Read

Causal cardiovascular risk factors for dementia: insights from observational and genetic studies.Semantic proximity Read

Genetically predicted high-density lipoprotein traits and pan-disease risk: a systematic review.Semantic proximity Read

Lipid lowering and Alzheimer disease risk: A mendelian randomization study.Semantic proximity Read

There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study.Semantic proximity Read