Article

Conformational plasticity and allosteric communication networks govern Shelterin protein TPP1 binding to human telomerase

2023-02-03

Abstract excerpt

The molecular binding interaction between the Shelterin complex protein TPP1 and human telomerase enzyme (TERT) triggers the telomerase maintenance mechanism that marks cell lifespan. The TPP1’s structural element deputed to bind TERT is the OB-domain, which is able to interact with TERT’s hTEN (TPP1 binding telomerase domain) through the TEL-patch, a group of amino acids whose mutations provoke harsh pathologies....

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Literature Corpus work: 3eca2e10-f84f-5042-bfef-cff07aeddfa9
DOI: 10.1101/2023.02.02.526655

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