Article

NAMPT/NAD+ signaling drives neutrophil dysfunction and enhances bacterial infection susceptibility in cancer patients

2025-03-24

Abstract excerpt

<title>Abstract</title> <p>Despite advancements in cancer therapies, bacterial complications remain a major challenge, delaying treatment and worsening outcomes. While immunosuppressive therapies and prolonged hospitalizations contribute, they do not fully explain the elevated infection risk in cancer patients. We observed that elevated G-CSF production by tumors was associated with the persistence of Gram-negati...

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Literature Corpus work: 3eaa61e9-1569-5480-9680-154c98a54caa
DOI: 10.21203/rs.3.rs-6098692/v1

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