Article
Serpins A1/A3 within tumor-derived extracellular vesicles support pro-tumoral bias of neutrophils in cancer
2025-03-07
Abstract excerpt
Neutrophils are known to play an important regulatory role during tumor progression in several types of cancer. However, the mechanisms responsible for their tumorigenic bias and extended lifespan in cancer are not clear to date. This study uncovers a previously unknown mechanism by which tumor-derived small extracellular vesicles (sEVs), via their serpin cargo, reprogram neutrophils to adopt a tumor-supporting ph...
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Identifiers and source
- Literature Corpus work
- ab0c62c7-4132-5f0b-9637-6e64239c5fbc
- DOI
- 10.1101/2025.03.06.641593