Article
High-throughput discovery of novel developmental phenotypes.
Nature - 22 Sept 2016
Dickinson Mary E, Flenniken Ann M, Ji Xiao, Teboul Lydia, Wong Michael D, White Jacqueline K, Meehan Terrence F, Weninger Wolfgang J, Westerberg Henrik, Adissu Hibret, Baker Candice N, Bower Lynette, Brown James M, Caddle L Brianna, Chiani Francesco, Clary Dave, Cleak James, Daly Mark J, Denegre James M, Doe Brendan, Dolan Mary E, Edie Sarah M, Fuchs Helmut, Gailus-Durner Valerie, Galli Antonella, Gambadoro Alessia, Gallegos Juan, Guo Shiying, Horner Neil R, Hsu Chih-Wei, Johnson Sara J, Kalaga Sowmya, Keith Lance C, Lanoue Louise, Lawson Thomas N, Lek Monkol, Mark Manuel, Marschall Susan, Mason Jeremy, McElwee Melissa L, Newbigging Susan, Nutter Lauryl M J, Peterson Kevin A, Ramirez-Solis Ramiro, Rowland Douglas J, Ryder Edward, Samocha Kaitlin E, Seavitt John R, Selloum Mohammed, Szoke-Kovacs Zsombor, Tamura Masaru, Trainor Amanda G, Tudose Ilinca, Wakana Shigeharu, Warren Jonathan, Wendling Olivia, West David B, Wong Leeyean, Yoshiki Atsushi, MacArthur Daniel G, Tocchini-Valentini Glauco P, Gao Xiang, Flicek Paul, Bradley Allan, Skarnes William C, Justice Monica J, Parkinson Helen E, Moore Mark, Wells Sara, Braun Robert E, Svenson Karen L, de Angelis Martin Hrabe, Herault Yann, Mohun Tim, Mallon Ann-Marie, Henkelman R Mark, Brown Steve D M, Adams David J, Lloyd K C Kent, McKerlie Colin, Beaudet Arthur L, Bućan Maja, Murray Stephen A
Abstract excerpt
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As part of the International Mouse Phenotyping Consortium effort to generate and phenotypically characterize 5,000 knockout mouse lines, here we identify 410 lethal genes during the production of the first...
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