Article
Simultaneous cellular and molecular phenotyping of embryonic mutants using single-cell regulatory trajectories.
Developmental cell - 28 Feb 2022
Secchia Stefano, Forneris Mattia, Heinen Tobias, Stegle Oliver, Furlong Eileen E M
Abstract excerpt
Developmental progression and cellular diversity are largely driven by transcription factors (TFs); yet, characterizing their loss-of-function phenotypes remains challenging and often disconnected from their underlying molecular mechanisms. Here, we combine single-cell regulatory genomics with loss-of-function mutants to jointly assess both cellular and molecular phenotypes. Performing sci-ATAC-seq at eight...
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