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Age-dependent acceleration of structural brain aging in medication-free major depressive disorder linked to neuroanatomical phenotype findings from COORDINATE-MDD consortium

2026-04-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Major depressive disorder (MDD) is associated with altered brain structure and evidence of accelerated brain aging. However, previous studies have been limited by clinical samples with mixed medication status and multiple mood states, modest sample sizes, small percentage of MDD individuals older than 65 years of age, and/or reliance on summary-level data. <h4>Methods</h4>...

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Literature Corpus work
3e83d9e1-7f83-5553-9c84-0e7f9ac6be64
DOI
10.64898/2026.03.31.26349338
Open publication

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Age-dependent acceleration of structural brain aging in medication-free major depressive disorder linked to neuroanatomical phenotype findings from COORDINATE-MDD consortiumDOI 10.64898/2026.03.31.26349338
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