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Accelerated brain aging in patients with major depressive disorder and its neurogenetic basis: evidence from neurotransmitters and gene expression profiles

1 Jan 2025

Abstract excerpt

BACKGROUND: Numerous studies have explored the relationship between brain aging and major depressive disorder (MDD) and attempted to explain the phenomenon of faster brain aging in patients with MDD from multiple perspectives. However, a major challenge in this field is elucidating the ontological basis of these changes. Here, we aimed to explore the relationship between brain structural changes in MDD-related...

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PMID: 40041978
DOI: 10.1017/s0033291725000418

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