Article

Alpha-synuclein supports interferon stimulated gene expression in neurons

2020-04-27

Abstract excerpt

The protein alpha-synuclein (asyn) is predominantly expressed in neurons and is associated with neurodegenerative diseases like Parkinson’s disease (PD); yet, a functional role for asyn in neurons is not clearly established. We have previously shown that asyn expression is up-regulated following viral infection in neurons and is critical for host immune responses to RNA virus infections. Here, we investigate the m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e830d20-d894-5a90-91be-f74f24bb24ef
DOI: 10.1101/2020.04.25.061762

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alpha-synuclein supports interferon stimulated gene expression in neuronsDOI 10.1101/2020.04.25.061762Read

Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cellsSemantic proximity Read

Astrocytic RNA editing regulates the host immune response to alpha-synucleinSemantic proximity Read

Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's diseaseSemantic proximity Read

IFNγ drives neuroinflammation and demyelination in a mouse model of multiple system atrophySemantic proximity Read

Suppression of the JAK/STAT Pathway Inhibits Neuroinflammation in the Line 61-PFF Mouse Model of Parkinson’s DiseaseSemantic proximity Read

Alpha-synuclein expression in neuron modulates the Japanese encephalitis virus infectionSemantic proximity Read

Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson’s DiseaseSemantic proximity Read

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked MutantsSemantic proximity Read

Inhibition of T cell infiltration and soluble TNF signaling is neuroprotective in the alpha-synuclein overexpressing mouse model of Parkinson’s diseaseSemantic proximity Read

Adoptive NK cell transfer confers neuroprotection by attenuating neuroinflammation and alpha-synuclein pathology in a mouse model of synucleionpathySemantic proximity Read

Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse modelSemantic proximity Read

Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent ToxicitySemantic proximity Read