Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson’s Disease

10 Dec 2014

Abstract excerpt

Expression patterns of the alpha-synuclein gene (SNCA) were studied across anatomy, development, and disease to better characterize its role in the brain. In this postmortem study, negative spatial co-expression between SNCA and 73 interferon-γ (IFN-γ) signaling genes was observed across many brain regions. Recent animal studies have demonstrated that IFN-γ induces loss of dopamine neurons and nigrostriatal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25493648
DOI: 10.1371/journal.pone.0115029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson’s DiseasePMID 25493648Read ↗

Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.Semantic proximity Read ↗

Deregulation of α-synuclein in Parkinson’s disease: Insight from epigenetic structure and transcriptional regulation of SNCASemantic proximity Read ↗

Regulation of alpha-synuclein expression: implications for Parkinson's disease.Semantic proximity Read ↗

Glial α‐synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivoSemantic proximity Read ↗

Interplay between α-synuclein and parkin genes: Insights of Parkinson’s diseaseSemantic proximity Read ↗

The yin and yang of α-synuclein-associated epigenetics in Parkinson’s diseaseSemantic proximity Read ↗

Distinct and Combined Interferon-ɑ/β-receptor-1 Loss in Neurons and Astrocytes Disrupt Brain Energy Metabolism and Drive Parkinsonian DementiaSemantic proximity Read ↗

A topographical atlas of α-synuclein cell type-specific expression in adult mouse brain and peripheral organsSemantic proximity Read ↗

Differential Expression and Distribution of α-, β-, and γ-Synuclein in the Developing Human Substantia NigraSemantic proximity Read ↗

Altered α‐synuclein, parkin, and synphilin isoform levels in multiple system atrophy brainsSemantic proximity Read ↗

Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative DiseaseSemantic proximity Read ↗

Synucleins and Gene Expression: Ramblers in a Crowd or Cops Regulating Traffic?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.