Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cells

9 Jan 2024

Abstract excerpt

BACKGROUND: Increasing evidence suggests a double-faceted role of alpha-synuclein (α-syn) following infection by a variety of viruses, including SARS-CoV-2. Although α-syn accumulation is known to contribute to cell toxicity and the development and/or exacerbation of neuropathological manifestations, it is also a key to sustaining anti-viral innate immunity. Consistently with α-syn aggregation as a hallmark of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Long-Term Effects of COVID-19
Share to Multiple Sclerosis Research Studies
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38191441
DOI: 10.1186/s40659-023-00482-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cellsPMID 38191441Read ↗

Alpha-synuclein expression in neuron modulates the Japanese encephalitis virus infectionSemantic proximity Read ↗

Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's diseaseSemantic proximity Read ↗

The good and bad of therapeutic strategies that directly target α‐synucleinSemantic proximity Read ↗

Alpha-synuclein supports interferon stimulated gene expression in neuronsSemantic proximity Read ↗

SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In VitroSemantic proximity Read ↗

Alpha-Synuclein Dysregulation in Systemic Pathophysiology of SynucleinopathiesSemantic proximity Read ↗

IFNγ alters the aberrant phenotype of α-synuclein-treated microglia reducing the detrimental impact of their secretome on dopaminergic neurons.Semantic proximity Read ↗

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked MutantsSemantic proximity Read ↗

Inflammation drives synucleinopathy propagationSemantic proximity Read ↗

Alpha-Synuclein, a Novel Viral Restriction Factor Hiding in Plain SightSemantic proximity Read ↗

Immunoregulation of Microglia M2 polarization is an unrecognized physiological function of α -SynucleinSemantic proximity Read ↗

Astrocytic RNA editing regulates the host immune response to alpha-synucleinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.