Article

Synthetic gene circuits that selectively target RAS-driven cancers

2024-11-11

Abstract excerpt

Therapies targeting mutated RAS, the most frequently mutated oncogene in human cancers, could benefit millions of patients. Recently approved RAS inhibitors represent a breakthrough, but are limited to a specific KRAS G12C mutation and prone to resistance. Synthetic gene circuits offer a promising alternative by sensing and integrating cancer-specific biomolecular inputs, including mutated RAS, to selectively exp...

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Literature Corpus work: 3e577ae8-18b2-5d8a-a003-ec7cc573fdad
DOI: 10.1101/2024.11.11.622942

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