Article

Multi-ancestry Genome-wide Association Study of Inpatient Opioid Exposure Following Knee or Hip Arthroplasty

2025-07-24

Abstract excerpt

Opioids are commonly prescribed to manage acute postoperative pain. However, there is considerable variability in opioid administration patterns and practices, which is partially attributable to patient characteristics. We used electronic health record (EHR) and genotype data from the Million Veteran Program sample to investigate genetic predictors of individual differences in inpatient opioid analgesic exposure f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e501798-377a-5ba8-a0b8-e6a9ded07c75
DOI: 10.1101/2025.07.23.25331996

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-ancestry Genome-wide Association Study of Inpatient Opioid Exposure Following Knee or Hip ArthroplastyDOI 10.1101/2025.07.23.25331996Read

A multi-ancestry genetic study of pain intensity in 598,339 veterans.Semantic proximity Read

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brainSemantic proximity Read

The design and methods of genetic studies on acute and chronic postoperative pain in patients after total knee replacement.Semantic proximity Read

Genetic associations of persistent opioid use after surgery: a hypothesis-driven analysis of high-value genetic variants in the Michigan Genomics Initiative datasetSemantic proximity Read

Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder.Semantic proximity Read

Human Genetic Variability Contributes to Postoperative Morphine Consumption.Semantic proximity Read

Optimizing Control Definitions in Opioid Use Disorder Genetic Research Using Electronic Health RecordsSemantic proximity Read

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brainSemantic proximity Read

Association of OPRM1 Functional Coding Variant With Opioid Use DisorderSemantic proximity Read

Feasibility of pharmacogenetic-guided selection of postoperative analgesics in gynecologic surgery patients: a prospective, randomized, pilot study.Semantic proximity Read

Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.Semantic proximity Read

Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients.Semantic proximity Read