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Optimizing Control Definitions in Opioid Use Disorder Genetic Research Using Electronic Health Records

Addiction biology - 1 Jan 2026

Niarchou Maria, Tsai Ellen L, Jennings Mariela V, Faucon Annika, Lee Hyunjoon, Singh Kritika, Tubbs Justin D, Roussos Panos, Ge Tian, Crist Richard C, Vickers-Smith Rachel, Edenberg Howard, Moore Amy, Webb Bradley T, Johnson Eric O, Kember Rachel L, Smoller Jordan W, Davis Lea K, Coombes Brandon J, Voloudakis Georgios, Burstein David, Mallard Travis T, Troiani Vanessa, Sanchez-Roige Sandra

Abstract excerpt

Amidst the opioid crisis, understanding the genetic basis of opioid use disorder (OUD) is crucial for identifying biological mechanisms and intervention points. However, genome-wide association studies (GWASs) have been hampered by inadequate sample sizes and often the use of control populations not assessed for prior opioid exposure. Because opioid exposure is a prerequisite for the development of OUD,...

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Source

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Identifiers

PMID: 41549723
DOI: 10.1111/adb.70094
PMCID: PMC12813555

Genes

OPRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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