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Article

A multi-ancestry genetic study of pain intensity in 598,339 veterans.

Nature medicine - 1 Apr 2024

Toikumo Sylvanus, Vickers-Smith Rachel, Jinwala Zeal, Xu Heng, Saini Divya, Hartwell Emily E, Pavicic Mirko, Sullivan Kyle A, Xu Ke, Jacobson Daniel A, Gelernter Joel, Rentsch Christopher T, Stahl Eli, Cheatle Martin, Zhou Hang, Waxman Stephen G, Justice Amy C, Kember Rachel L, Kranzler Henry R

Abstract excerpt

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects the quality of life and imposes substantial personal and economic costs. Efforts to treat chronic pain using opioids had a central role in precipitating the opioid crisis. Despite an estimated heritability of 25-50%, the genetic architecture of chronic pain is not...

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Chronic Pain
Genetic Predisposition to Disease
Genome-Wide Association Study
Pain Measurement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quality of Life

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Identifiers

PMID: 38429522
DOI: 10.1038/s41591-024-02839-5
PMCID: PMC12105102

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