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Article

Human Genetic Variability Contributes to Postoperative Morphine Consumption.

The journal of pain - 1 May 2016

De Gregori Manuela, Diatchenko Luda, Ingelmo Pablo M, Napolioni Valerio, Klepstad Pal, Belfer Inna, Molinaro Valeria, Garbin Giulia, Ranzani Guglielmina N, Alberio Giovanni, Normanno Marco, Lovisari Federica, Somaini Marta, Govoni Stefano, Mura Elisa, Bugada Dario, Niebel Thekla, Zorzetto Michele, De Gregori Simona, Molinaro Mariadelfina, Fanelli Guido, Allegri Massimo

Abstract excerpt

UNLABELLED: High interindividual variability in postoperative opioid consumption is related to genetic and environmental factors. We tested the association between morphine consumption, postoperative pain, and single nucleotide polymorphisms (SNPs) within opioid receptor μ 1 (OPRM1), catechol-O-methyltransferase (COMT), uridine diphosphate glucose-glucuronosyltransferase-2B7, and estrogen receptor (ESR1) gene...

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Share to Analgesics, Opioid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26902643
DOI: 10.1016/j.jpain.2016.02.003

Genes

ESR1
OPRM1
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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