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Article

FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity.

Proceedings of the National Academy of Sciences of the United States of America - 17 Oct 2017

Delpoux Arnaud, Lai Chen-Yen, Hedrick Stephen M, Doedens Andrew L

Abstract excerpt

The factors and steps controlling postinfection CD8+ T cell terminal effector versus memory differentiation are incompletely understood. Whereas we found that naive TCF7 (alias "Tcf-1") expression is FOXO1 independent, early postinfection we report bimodal, FOXO1-dependent expression of the memory-essential transcription factor TCF7 in pathogen-specific CD8+ T cells. We determined the early postinfection TCF7high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28973925
DOI: 10.1073/pnas.1618916114
PMCID: PMC5651728

Genes

TCF7
FOXO1
GZMB
BCL2
EOMES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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