Article

Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors

2023-11-03

Abstract excerpt

<title>Abstract</title> <p>The efficacy of chimeric antigen receptor (CAR) T cell therapy is limited in solid tumors by several factors including the immunosuppressive tumor microenvironment that gives rise to poorly persisting and metabolically dysfunctional T cells. To overcome this, we sought to identify transcription factors that could enhance CAR T cell fitness. We identified that the overexpression of Foxo1...

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Literature Corpus work: 606a8d38-448a-5734-becb-af7ad9809f1f
DOI: 10.21203/rs.3.rs-2584153/v1

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