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Supercharging CAR-T cells through transcriptional and epigenetic armoring

18 Feb 2025

Abstract excerpt

Inspired by the remarkable success of CAR-T therapy in hematologic malignancies, research is increasingly focused on adapting this treatment for solid tumors. However, CAR-T efficacy remains limited due to its exhaustion and shortened persistence. Transcription factors and epigenetic modifications play pivotal roles in modulating T cell differentiation and functionality, which have been leveraged in numerous...

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PMID: 40093905
DOI: 10.7150/thno.107908

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