Article

Systems genetics analyses in Diversity Outbred mice inform human bone mineral density GWAS and identify <i>Qsox1</i> as a novel determinant of bone strength

2020-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, we used Diversity Outbred (DO) mice to directly address these limitations by performing the first systems genetics analysis of 55 complex skeletal ph...

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Literature Corpus work: 3e300dec-5641-5d9b-9502-6047f10647df
DOI: 10.1101/2020.06.24.169839

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