Article

ADGRG1 blockade drives astrocytes into the extracellular matrix to reduce glial scar size

2026-08-12

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> After wide range of traumatic damage to the spinal cord, reactive astrocytes migrate toward the lesion but stop at the edge of the fibrotic extracellular matrix (ECM) core. There, the reactive astrocytes accumulate and form the glial scar border that prevents the regenerating axons from passing through. Why these astrocytes stop at this border rather than ente...

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Literature Corpus work: 42b100c9-b49b-5928-b915-1d0abbd928e2
DOI: 10.21203/rs.3.rs-10546825/v1

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