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Hippocampal CA3 Nex/Neurod6 <sup>+</sup> neuron-specific TNFR2 alleviates chronic neuropathic pain by sex-dependently engaging opioid and endocannabinoid pathways

2025-11-28

Abstract excerpt

Chronic neuropathic pain (CNP) develops as a result of persistent neuroinflammation and maladaptive synaptic plasticity in the central nervous system following nerve injury. While tumor necrosis factor receptor 2 (TNFR2) signaling has been extensively studied in pain resolution, the expression of this receptor on specific neuronal populations and molecular pathways involved in spontaneous pain recovery still remai...

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Literature Corpus work
3e1b5d54-e87b-54f2-9712-4fc921b76d93
DOI
10.1101/2025.11.24.690195
Open publication

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Hippocampal CA3 Nex/Neurod6 <sup>+</sup> neuron-specific TNFR2 alleviates chronic neuropathic pain by sex-dependently engaging opioid and endocannabinoid pathwaysDOI 10.1101/2025.11.24.690195
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