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Conserved Axonal Transcriptome Dynamics Underlie PGE <sub>2</sub> -Induced Sensitisation and Identify <i>Tnfrsf12a/</i> Fn14 as a Regulator of Neuronal Excitability in DRG Neurons

2025-09-07

Abstract excerpt

Chronic pain arises when dorsal root ganglion (DRG) neurons become sensitised to noxious inputs, a process driven by inflammatory mediators such as prostaglandin E 2 (PGE 2 ). Local translation of axonal mRNAs is a key regulator of nociceptor plasticity, yet how axonal transcriptome dynamics contribute to inflammatory sensitisation remains unclear. Using compartmentalised culture systems and RNA-sequencing, we d...

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Literature Corpus work
210e7c0d-32b3-5243-9598-9c3eada40f0e
DOI
10.1101/2025.09.02.673723
Open publication

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Conserved Axonal Transcriptome Dynamics Underlie PGE <sub>2</sub> -Induced Sensitisation and Identify <i>Tnfrsf12a/</i> Fn14 as a Regulator of Neuronal Excitability in DRG NeuronsDOI 10.1101/2025.09.02.673723
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