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Article

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.

Nature medicine - 1 May 2015

Vicuña Lucas, Strochlic David E, Latremoliere Alban, Bali Kiran Kumar, Simonetti Manuela, Husainie Dewi, Prokosch Sandra, Riva Priscilla, Griffin Robert S, Njoo Christian, Gehrig Stefanie, Mall Marcus A, Arnold Bernd, Devor Marshall, Woolf Clifford J, Liberles Stephen D, Costigan Michael, Kuner Rohini

Abstract excerpt

Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identification of novel targets for pain therapy, classical study designs provide unclear results owing to the differential expression of hundreds of genes across sham and nerve-injured groups, which can be difficult to validate, particularly...

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Identifiers

PMID: 25915831
DOI: 10.1038/nm.3852
PMCID: PMC4450999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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