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TNFR1/p38αMAPK signaling in Nex+ supraspinal neurons regulates sex-specific chronic neuropathic pain

2023-08-03

Abstract excerpt

<h4>ABSTRACT</h4> Upregulation of soluble tumor necrosis factor (sTNF) cytokine signaling through TNF receptor 1 (TNFR1) and subsequent neuronal hyperexcitability are observed in both animal models and human chronic neuropathic pain (CNP) (Clark et al., 2013; Empl et al., 2001; Ji et al., 2018; Lindenlaub and Sommer, 2003). To test the hypothesis that supraspinal circuitry is critical to pain chronification, we s...

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Literature Corpus work
8b95a02f-4147-57a3-9f8d-80023abb8f40
DOI
10.1101/2023.08.01.551503
Open publication

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TNFR1/p38αMAPK signaling in Nex+ supraspinal neurons regulates sex-specific chronic neuropathic painDOI 10.1101/2023.08.01.551503
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