Article

FMRP activates the translation of large autism/intellectual disability proteins and stimulates N-end rule E3 ligase Poe/UBR4 production within puromycin-sensitive RNP particles

2020-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in Fmr1, encoding the RNA binding protein FMRP, are leading causes of intellectual disability, autism, and female infertility, but FMRP’s mechanism of action is controversial. In contrast to its previously postulated function as a translation repressor acting by stalling elongation, we recently found that FMRP activates translation initiation of large proteins in Drosophila oocytes up...

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Literature Corpus work: 3e17c758-ed2e-5d6f-a0c5-b2d2fe4f9df2
DOI: 10.1101/2020.06.27.174136

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FMRP activates the translation of large autism/intellectual disability proteins and stimulates N-end rule E3 ligase Poe/UBR4 production within puromycin-sensitive RNP particlesDOI 10.1101/2020.06.27.174136Read

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