Article

Widespread Alterations in Translation Elongation in the Brain of Juvenile <i>Fmr1</i> Knock-Out Mice

2018-05-10

Abstract excerpt

<h4>Summary</h4> FMRP is a polysome-associated RNA-binding protein encoded by Fmr1 that is lost in Fragile X syndrome. Increasing evidence suggests that FMRP regulates both translation initiation and elongation, but the gene-specificity of these effects is unclear. To elucidate the impact of Fmr1 loss on translation, we used ribosome profiling for genome-wide measurements of ribosomal occupancy and positioning...

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Literature Corpus work: 839c597c-bcb5-593e-947e-4b7a44868a25
DOI: 10.1101/319368

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