Article

Fragile X mental retardation protein is a size-dependent translational activator

2018-01-31

Abstract excerpt

<h4>Summary</h4> FMR1 enhances translation of large neural/oocyte proteins Mutations in the highly conserved Fragile X mental retardation gene (Fmr1) cause the most common inherited human intellectual disability/autism spectrum disorder. Fmr1 is also needed for ovarian follicle development, and lesions are the largest genetic cause of premature ovarian failure (POF). FMR1 associates with ribosomes and is though...

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Literature Corpus work: db623f7a-8cef-5553-b5e5-f3a70464597f
DOI: 10.1101/257204

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